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Psychology Department
   
Edward Castañeda    

Edward Castañeda
   
Personal Information    

Ph.D., University of Michigan (1987)

Professor

Curriculum Vitae

Behavioral Neuroscience Lab


   
Research Interests    

          Dr. Castañeda investigates plasticity in presynaptic mechanisms that modulate neurotransmitter release during changes in behavior due to neurodegeneration or substance abuse.  It is interesting to speculate how fundamental mechanisms that govern learning and memory might serve for compensation in surviving dopamine neurons of the brain compromised by Parkinson's disease and how these same mechanisms might play a role in the sensitization of dopamine neurons by repeated exposure to stimulant drugs.  Currently funded research seeks to understand how sensitization of amphetamine-evoked dopamine release may produce cross-sensitization to stimulant drug-conditioned environmental cues or stress.  To accomplish this, Dr. Castañeda incorporates in vivo intracerebral microdialysis to collect dopamine overflow evoked by drug and electrical stimulation of dopamine pathways.  Understanding the principles of cross-sensitization will provide insights regarding drug craving and recidivism in recovering addicts.
   
Sample Publications    

Chandler-Laney, P.C., Castañeda, E., Pritchett, C.E., Smith, M.L., Giddings, M., Artiga, A.I. & Boggiano, M.M.  (2007) A history of caloric restriction induces neurochemical and behavioral changes in rats consistent with models of depression. Pharmacol. Biochem. Behav., 87:104-114.

Trujillo, K.A., Castañeda, E., Martínez, D. & González, G.  (2006) Biological research on drug abuse and addiction in Hispanics:  current status and future directions.  Drug and Alcohol Dependence, 84S:S17-S28.

Castañeda, E., Fleming, S., Paquette, M., Boat, K., Moffett, J., Stachowiak, E.K., Bloom, D.C. & Stachowiak, M.K. (2005). Gene therapy assessment in the hemiparkinson rat:  drug-induced rotation is inadequate.  Physiol. Behav., 84(4), 525-535.

Duvauchelle, C.L., Ikegami, A. & Castañeda, E. (2000) Conditioned increases in behavioral activity and accumbens dopamine levels produced by intravenous cocaine.  Behav. Neurosci., 114:1156-1166.

Friedman, S.D., Castañeda, E. and Hodge, G.K. (1998) Long-term monoamine depletion, differential recovery, and subtle behavioral impairment following methamphetamine-induced neurotoxicity.  Pharmacol. Biochem. Behav., 61:35-44.

Tran-Nguyen, L.T.L., Castañeda, E. and MacBeth, T. (1996) Changes in behavior and monoamine levels in microdialysate from dorsal striatum after 6-OHDA infusions into ventral striatum.  Pharmacol. Biochem. Behav., 55:141-150.
   
Contact Information    

Email: ecastaneda9@utep.edu

Phone: 915 747-6558
Fax: 915 747-6553

109 Psychology Bldg.
Department of Psychology
University of Texas at El Paso
El Paso, TX 79968

   
Courses    

PSYC 4324 - Psychobiology
PSYC 5372 - Behavioral Neuroscience

   
Other Resources